In 2014, Takayama et al. [38] initial attempted to elucidate the in vitro metabolism of ADB-FUBINACA by analysing the metabolites produced by the exercise of the cytochrome P450 enzymes right after 1 h of incubation with human liver microsomes. Making use of UPLC/ESI-MS/MS, the authors recognized a single metabolite, resulting from oxidation on the